{"id":715,"date":"2022-08-29T23:41:30","date_gmt":"2022-08-29T23:41:30","guid":{"rendered":"http:\/\/seleniumlab.pbrc.hawaii.edu\/?page_id=715"},"modified":"2023-10-23T03:43:46","modified_gmt":"2023-10-23T03:43:46","slug":"research","status":"publish","type":"page","link":"https:\/\/seleniumlab.pbrc.hawaii.edu\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\t\t
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Research Projects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Our research encompasses cellular, molecular and physiological aspects of selenium biology<\/strong>.<\/p>\n

We focus on understanding the how selenium metabolism <\/strong>controls redox homeostasis, energy expenditure and contributes to the development of obesity. We use mouse and cell culture as models.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"Se-Recycling\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Lab Projects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tImpact of Se deficiency in cardiovascular function<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

\u00a0<\/p>

\"\"<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tSe effects on lipid metabolism in adipocytes<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

How Se deficiency impacts adipocyte function? Is an intact Se metabolism required for lipid accumulation and redox control?<\/p>

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tProtective role of Se against negative effects of glucocorticoids<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Although the stress response helps an organism adapt to a challenging environment, chronic exposure to stressful stimuli can have negative\u00a0consequences. Prolonged elevation of glucocorticoid stress hormones, widely prescribed as anti-inflammatory and immuno-suppressive medications, can cause metabolic disturbances, such as over-eating and excess weight gain, as well as neurological symptoms in humans. Our lab investigates the potential for the essential micronutrient selenium to counteract the negative effects of glucocorticoids on a cellular\u00a0and whole-body level. We have revealed a protective role for selenium against glucocorticoid-induced obesity in mice and are working to determine the underlying mechanisms, with a special emphasis on the brain and other tissues involved in energy balance.<\/p>

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tEvolutionary history of selenocysteine lyase<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Or: building the phylogenetic tree for the Se recycling enzyme.<\/p>

\"\"<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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All publications <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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See all publications in the last 5 years<\/a> \u00a0\"\"<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Research Projects Our research encompasses cellular, molecular and physiological aspects of selenium biology. We focus on understanding the how selenium metabolism controls redox homeostasis, energy expenditure and contributes to the development of obesity. We use mouse and cell culture as models. Lab Projects Impact of Se deficiency in cardiovascular function \u00a0 Se effects on lipid metabolism […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-715","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/seleniumlab.pbrc.hawaii.edu\/index.php\/wp-json\/wp\/v2\/pages\/715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/seleniumlab.pbrc.hawaii.edu\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/seleniumlab.pbrc.hawaii.edu\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/seleniumlab.pbrc.hawaii.edu\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/seleniumlab.pbrc.hawaii.edu\/index.php\/wp-json\/wp\/v2\/comments?post=715"}],"version-history":[{"count":92,"href":"https:\/\/seleniumlab.pbrc.hawaii.edu\/index.php\/wp-json\/wp\/v2\/pages\/715\/revisions"}],"predecessor-version":[{"id":2131,"href":"https:\/\/seleniumlab.pbrc.hawaii.edu\/index.php\/wp-json\/wp\/v2\/pages\/715\/revisions\/2131"}],"wp:attachment":[{"href":"https:\/\/seleniumlab.pbrc.hawaii.edu\/index.php\/wp-json\/wp\/v2\/media?parent=715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}